In the millenium version of this classic Gothic horror we find Abraham Van Helsing (Plummer), who has tangled with Count Dracula (Butler) in the past, working as an English antiques dealer. Simon (Miller) is a vampire hunter in training under his apprenticeship.
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During a late night taping of “Dr. Nasty’s Cavalcade of Horror”, bloody chaos takes place during the screening of two features (“Dinner for Monsters” and “Slit”). Samantha/Nurse Nasty is frustrated by how the show is being run by its womanizing director and its drunk and crazy host Dr. Nasty.
Set in the Mayan civilization, when a man’s idyllic presence is brutally disrupted by a violent invading force, he is taken on a perilous journey to a world ruled by fear and oppression where a harrowing end awaits him. Through a twist of fate and spurred by the power of his love for his woman and his family he will make a desperate break to return home and to ultimately save his way of life.
The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.
As the war between the vampires and the Lycans rages on, Selene, a former member of the Death Dealers (an elite vampire special forces unit that hunts werewolves), and Michael, the werewolf hybrid, work together in an effort to unlock the secrets of their respective bloodlines.